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The Accidental Law: Why 0.05 Rules Science and Why the ASA Wants It Gone
In modern research, the value p = 0.05 often functions as a magical cliff edge. If a result lands on 0.049, it is celebrated as a discovery; if it lands on 0.051, it is dismissed as noise. This rigid threshold determines funding, publication, and drug approvals. Yet, there is no mathematical derivation that proves 0.05 is the "correct" threshold for truth. It is arguably the most influential number in science, but its dominance is essentially an accident of history—a fossil o

Christos Nikolaou
Nov 24, 20253 min read


Why Statistics Do Not Always Reflect Reality
The Parable of the Two Exams In science, we often treat the p-value as a definitive verdict on reality. If a study reports a "significant" result ( p < 0.05 ), we assume the effect is real. If it reports a "non-significant" result ( p > 0.05 ), we assume the effect doesn't exist. However, statistics are not a direct measure of reality; they are a measure of uncertainty . And uncertainty depends entirely on the design of the experiment, not just on the subject's talent. To und

Christos Nikolaou
Nov 23, 20254 min read


Orthopaedic Stainless Steel vs Titanium: Strength, Springiness, and Stamina
I often hear from colleagues that stainless steel implants are stronger than titanium ones, and from others that the opposite is true. It turns out both are right, depending on what you mean by "strong." I created a chart of the most common implant materials used in traumatology in Granda EduPack, based on the most up-to-date database (2023). The fatigue graphs are from the same source. When we talk about a material being "strong" for an implant, we're often bundling several

Christos Nikolaou
Nov 15, 20258 min read


Comments on the Effect of an Orthogonal Locking Plate and Primary Plate Working Length on Construct Stiffness and Plate Strain in an In Vitro Fracture-Gap Model
My Comments on the Article You can find my letter to the editor here . The authors' reply can be found here . This study demonstrates significant effort by the researchers, whose primary concern was whether the working length of an implant affects its stress/strain. For this, they used constructs with different working lengths and measured the strain at the middle part of the plate. They stated that they chose four-point bending to ensure a constant bending moment along the l

Christos Nikolaou
Nov 13, 20256 min read



Christos Nikolaou
Jul 24, 20250 min read



Christos Nikolaou
Jul 23, 20250 min read



Christos Nikolaou
Jul 22, 20250 min read



Christos Nikolaou
Jul 22, 20250 min read



Christos Nikolaou
Jul 21, 20250 min read


Why do these locking screws don't lock? It may be my fault.
Occasionally, implants do not function as we planned due to technical mistakes. In other instances, it may be because there are usage...

Christos Nikolaou
Apr 26, 20251 min read
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